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KMID : 0605619970040020234
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Journal of Korean Society of Biological Psychiatry
1997 Volume.4 No. 2 p.234 ~ p.236
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Failure to Support Associations of Neurotrophin-3(NT-3) Gene Polymorphism in Korean Schizophrenic Patients
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Yu-sang Lee
Jin-Hee Han/Eun-Kee Chung/Byung Hwan Yang/Hyeong-Suob Kim/Jung Sik Lee/Yeon-Ho Joo/Young-Gyu Chai
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Abstract
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Though initial report from Japan showed positive association of schizophrenia with dinucleotide repeat polymorphism in the NT-3 gene, subsequent studies showed mixed results. Therefore we conducted a replication study with Korean schizophrenics and matched controls who share similar ethnic background with Japanese population. The frequency of allele of dinucleotide repeat at 147 base pairs in the NT-3 gene was slightly increased, however, failed to reach statistical significance(χ2=1.884, df=1, p<0.170) between the two groups. These findings do not support an association of NT-3 gene polymorphism with schizophrenia in Korean sample.
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KEYWORD
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Neurotrophin-3(NT-3), Dinucleotide repeat polymorphism, Association study, Schizophrenia,
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